New PTX-HS15/T80 Mixed Micelles: Cytotoxicity, Pharmacokinetics and Tissue Distribution

Compared with single micelle, the new PTX-HS15/T80 mixed micelle system (PTX-HS15/T80 MMs) had achieved better results in solubilization, stability, and sensitization before. Therefore, we intend to further verify potential advantages of delivery through vitro cytotoxicity test animal understand anticancer effect vivo pharmaceutical behavior system. In showed that MMs a stronger ability inhibit proliferation cancer cells. The pharmacokinetics shorter half-life, higher clearance rate, lower blood concentration good characteristics. tissue distribution that, compared Taxol®, characteristics lung (AUC (lung 0–4 H) increased about 26%) low heart (Heart decreased 10%). Paclitaxel was mainly metabolized liver kidney. above suggested may have certain therapeutic against reduce toxic side effects. general, not only simple cheap prepare but also vivo, indicating combination surfactants provides choice for solving problem insoluble drug delivery.